Intern
    Prof. Dr. Reinhold Tacke

      

    Sila-haloperidol: A Silicon Analogue of the Dopamine Antagonist Haloperidol

     


    Synthesis of Sila-haloperidol


    Receptor Affinities of Haloperidol and Sila-haloperidol for the Dopamine hD1, hD2, hD3, hD4, and hD5 Receptor (Radioligand Binding Studies)

     


    Metabolism of Haloperidol and Sila-haloperidol


    Major in vitro Metabolites of Sila-haloperidol (Human Liver Microsomes, MS/MS Studies)

     


    R. Tacke, T. Heinrich, R. Bertermann, C. Burschka, A. Hamacher, M. U. Kassack, Organometallics 2004, 23, 4468–4477. more ...

    R. Tacke, F. Popp, B. Müller, B. Theis, C. Burschka, A. Hamacher, M. U. Kassack, D. Schepmann, B. Wünsch, U. Jurva, E. Wellner, ChemMedChem 2008, 3, 152–164. more...

    R. Tacke, T. Heinrich (Amedis Pharmaceuticals Ltd.), UK Pat. Appl. GB 2382575 A (04.06.2003). more...

    Kontakt

    Prof. Dr. Reinhold Tacke
    Institut für Anorganische Chemie
    Am Hubland
    97074 Würzburg

    Tel.: +49 931 31-85250
    Fax: +49 931 31-84609
    E-Mail

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    Hubland Süd, Geb. C4