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Deutsch Intern
    Prof. Dr. Reinhold Tacke

      

    Differences between Analogous Compounds of Carbon and Silicon

     

    Shape and Size
    Bonding Geometries
    Conformational Flexibility
    Charge Distribution
    Lipophilicity
    Chemical Reactivity, etc.

    Biological Activity?
    C/Si Bioisosterism?
    Biological Sila-Substitution Effects?

     


    Reviews: W. Bains, R. Tacke, Curr. Opin. Drug Discovery Dev. 2003, 6, 526–543.

    R. Tacke, H. Linoh, in: The Chemistry of Organic Silicon Compounds, Part 2 (Eds.: S. Patai, Z. Rappoport), John Wiley & Sons Ltd., Chichester, 1989, 1143-1206.

    Patents: D. Miller, G.A. Showell, R. Conroy, J. Daiss, R.Tacke, D. Tebbe (Amedis Pharmaceuticals Ltd.), PCT Int. Pat. Appl. WO 2005/005443 A1 (08.06.2004). more ...

    J. G. Montana, A. G. Showell, I. Fleming, R. Tacke, J. Daiss (Inventors), Amedis Pharmaceuticals Ltd., Cambridge, U.K., PCT Int. Pat. Appl. WO 2004/048390 A1 (10.06.2004). more ...

    J. G. Montana, G. A. Showell, R. Tacke (Inventors), Amedis Pharmaceuticals Ltd., Cambridge, U.K., PCT Int. Pat. Appl. WO 2004/048391 A1 (10.06.2004). more ...

    J.G. Montana, I. Fleming, R.Tacke, J. Daiss (Amedis Pharmaceuticals Ltd.), PCT Int. Pat. Appl. WO 2004/045625 A1 (03.06.2004). more ...

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    Contact

    Prof. Dr. Reinhold Tacke
    Institut für Anorganische Chemie
    Am Hubland
    97074 Würzburg

    Phone: +49 931 31-85250
    Fax: +49 931 31-84609
    Email

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    Hubland Süd, Geb. C4